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Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Luwor, Rodney; Morokoff, Andrew P; Amiridis, Stephanie; D'Abaco, Giovanna; Paradiso, Lucia; Stylli, Stanley S; Nguyen, Hong P T; Tarleton, Mark; Young, Kelly A; O'Brien, Terence J; Robinson, Phillip J; Chircop, Megan; McCluskey, Adam; Jones, Nigel C.
Afiliação
  • Luwor R; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Morokoff AP; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Amiridis S; b Department of Neurosurgery , The Royal Melbourne Hospital , Parkville , Australia.
  • D'Abaco G; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Paradiso L; c Department of Medicine , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Stylli SS; d Melbourne School of Engineering, School of Chemical and Biomedical Engineering , The University of Melbourne , Parkville , Australia.
  • Nguyen HPT; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Tarleton M; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Young KA; b Department of Neurosurgery , The Royal Melbourne Hospital , Parkville , Australia.
  • O'Brien TJ; a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Robinson PJ; e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.
  • Chircop M; e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.
  • McCluskey A; c Department of Medicine , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
  • Jones NC; f Department of Neuroscience , Central Clinical School, Monash University , Melbourne , Australia.
Cancer Invest ; 37(3): 144-155, 2019.
Article em En | MEDLINE | ID: mdl-30907150
ABSTRACT
Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias Encefálicas / Cianoacrilatos / Dinamina II / Glioma / Indóis Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias Encefálicas / Cianoacrilatos / Dinamina II / Glioma / Indóis Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article