BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.
Epilepsy Behav
; 94: 131-136, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30909076
ABSTRACT
OBJECTIVE:
The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) ε4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy.METHODS:
One hundred forty-eight adults (Mageâ¯=â¯38â¯years; 53% female) with refractory epilepsy completed self-report measures of mood, anxiety, and/or personality/psychopathology. Mann-Whitney U, t-tests, and Fisher's exact tests were used to determine if APOE4, BDNF Val66Met, or COMT Val158Met are associated with increased psychiatric symptomatology in people with epilepsy.RESULTS:
As a group, BDNF Met carriers reported greater symptoms of depression on the Personality Assessment Inventory (PAI) than those without a Met allele (pâ¯=â¯0.004); COMT Val carriers reported greater symptoms on the PAI Schizophrenia (pâ¯=â¯0.007), Antisocial Features (pâ¯=â¯0.04), and Alcohol Problems (pâ¯=â¯0.03) scales than noncarriers. On the individual level, a significantly greater proportion of BDNF Met carriers demonstrated elevated PAI Depression scores compared to those without a Met allele (pâ¯=â¯0.046). There was also a larger proportion of COMT Val carriers with elevated PAI Anxiety scores as compared to those without a Val allele (pâ¯=â¯0.036).SIGNIFICANCE:
This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Catecol O-Metiltransferase
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Fator Neurotrófico Derivado do Encéfalo
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Alelos
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Epilepsia Resistente a Medicamentos
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Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article