Influence of acute reduction of blood viscosity on endothelial function.
Clin Hemorheol Microcirc
; 72(3): 239-245, 2019.
Article
em En
| MEDLINE
| ID: mdl-30909194
ABSTRACT
BACKGROUND:
The relationship between blood viscosity (BV) and endothelial function is rather complex. An increase in BV causes an increase in blood flow resistance, with negative hemodynamic effects; on the other hand, a moderate increase in BV causes an increase in wall stress shear (WSS), and consequent beneficial effects. As a matter of fact, the effect of changes in BV on endothelial function is not yet clear.OBJECTIVES:
Aim of the present study was to evaluate in-vivo the effects of the acute reduction in BV on endothelial function, in healthy male subjects.METHODS:
Fourteen healthy male blood donors were studied before and 48 hours after blood donation. Blood and plasma viscosity were measured at 37C° with a cone-plate viscometer. Endothelial function was evaluated through flow mediated vasodilation (FMD).RESULTS:
Blood viscosity was reduced after blood donation (BV225 (cP) 4.53±0.59 vs.4.18±0.31, pâ<â0.05). FMD 50âs after cuff deflation was unchanged 6.23±3.84 vs. 6.62±4.81, pâ=âNS. The vasodilation, however, lasted longer and the area under the curve of FMD was significantly increased 8.74±8.77 vs.16.14±8.65, pâ<â0.005.CONCLUSIONS:
The present results demonstrate that the acute reduction of BV prolongs vasodilation, without affecting the amount of vasodilatation, possibly as adaptive reaction allowing more time for oxygen release.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Viscosidade Sanguínea
/
Endotélio Vascular
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article