Molecular markers in recurrent stage I, grade 1 endometrioid endometrial cancers.
Gynecol Oncol
; 153(3): 517-520, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30910249
ABSTRACT
OBJECTIVES:
Stage I, grade 1 endometrial cancers have low recurrence rates and often do not receive adjuvant therapy. We compared recurrent cases to matched non-recurrent controls to evaluate for molecular markers associated with higher risk of recurrence.METHODS:
A case-control study including all cases of recurrent stage I, grade 1 endometrioid endometrial cancer at one institution in a ten-year period. Cases were matched to controls by age, BMI, weight and stage. Molecular testing and immunohistochemistry were performed on archival tumor specimens microsatellite instability (MSI-H), mismatch repair status, POLE mutational status, and next-generation sequencing.RESULTS:
15 stage I, grade 1 endometrial cancer cases with recurrent disease and available tumor specimens were identified. CTNNB1 and MSI-H were present at significantly higher rates in cases than controls (CTNNB1 60% vs. 28%, OR 3.9, 95%CI 1.1-14.7, pâ¯=â¯0.04 and MSI-H 53% vs. 21%, OR 4.4, 95%CI 1.1-17.0, pâ¯=â¯0.03). POLE mutations were found in 0% of cases vs. 7% of controls (pâ¯=â¯0.54). Among specimens demonstrating microsatellite stability (MSS), 100% of cases vs. 26% of controls had CTNNB1 mutations (pâ¯<â¯0.001). CTNNB1 wild type tumors were MSI-H in 100% of cases vs. 19% of controls (pâ¯<â¯0.001).CONCLUSIONS:
Compared to controls, CTNNB1 mutation is present at significantly higher rates in recurrent stage I, grade 1 endometrial cancers and is found most commonly in MSS tumors. MSI-H is also present at significantly higher rates in recurrent cases. These markers may be useful for prognostic risk stratification and adjuvant therapy decision-making in this otherwise low-risk population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Endométrio
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Carcinoma Endometrioide
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Beta Catenina
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Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article