Highly efficient regio-selective ring-opening nucleophilic fluorination of aziridines and azetidines: access to ß- or γ-fluorinated amino acid derivatives.
Org Biomol Chem
; 17(15): 3797-3804, 2019 04 10.
Article
em En
| MEDLINE
| ID: mdl-30916695
ABSTRACT
Herein, we have presented a facile and efficient method of ring-opening nucleophilic fluorination of aziridines, affording highly regio-selective ß-fluorinated amines. Firstly, the example of ring-opening hydrofluorination of azetidines was reported. Then, the Olah's reagent also provided a promising method for the construction of enantioenriched ß-fluoro-α-amino acid derivatives, which could be used for the preparation of peptide-based bioactive molecules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Aziridinas
/
Aminas
/
Aminoácidos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article