Kujigamberoic acid A, a carboxylic acid derivative of kujigamberol, has potent inhibitory activity against the degranulation of RBL-2H3 cells.
Biosci Biotechnol Biochem
; 83(7): 1193-1196, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30917761
ABSTRACT
The aldehyde and carboxylic acid derivatives of kujigamberol were synthesized using pyridinium dichromate (PDC). The carboxylic acid derivative exhibited lower cytotoxicity and inhibited the degranulation of rat basophilic leukemia-2H3 (RBL-2H3) cells stimulated by thapsigargin more than kujigamberol. The carboxylic acid derivative was detected and isolated from the methanol extract of Kuji amber (MEKA) by the modified isolation procedure. Thus, it has been named as kujigamberoic acid A.
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Base de dados:
MEDLINE
Assunto principal:
Degranulação Celular
/
Diterpenos
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Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article