Tree-ensemble analysis assesses presence of multifurcations in single cell data.
Mol Syst Biol
; 15(3): e8552, 2019 03 27.
Article
em En
| MEDLINE
| ID: mdl-30918107
ABSTRACT
We introduce TreeTop, an algorithm for single cell data analysis to identify and assign a branching score to branch points in biological processes which may have multi-level branching hierarchies. We demonstrate branch point identification for processes with varying topologies, including T-cell maturation, B-cell differentiation and hematopoiesis. Our analyses are consistent with recent experimental studies suggesting a shallower hierarchy of differentiation events in hematopoiesis, rather than the classical multi-level hierarchy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Diferenciação Celular
/
Análise de Célula Única
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article