Molecular modeling of salsolinol, a full G<sub>i</sub> protein agonist of the µ-opioid receptor, within the receptor binding site.

Berríos-Cárcamo, Pablo; Rivera-Meza, Mario; Herrera-Marschitz, Mario; Zapata-Torres, Gerald

Molecular modeling of salsolinol, a full G_i protein agonist of the µ-opioid receptor, within the receptor binding site.

Berríos-Cárcamo, Pablo; Rivera-Meza, Mario; Herrera-Marschitz, Mario; Zapata-Torres, Gerald.

Afiliação

Berríos-Cárcamo P; Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Rivera-Meza M; Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Herrera-Marschitz M; Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Zapata-Torres G; Department of Analytical and Inorganic Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.

Chem Biol Drug Des ; 94(2): 1467-1477, 2019 08.

Article em En | MEDLINE | ID: mdl-30920734

Assuntos

Isoquinolinas/química; Simulação de Dinâmica Molecular; Receptores Opioides mu/agonistas; Sítios de Ligação; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Humanos; Receptores Opioides mu/química; Receptores Opioides mu/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

enantiomeric specificity; functional selectivity; molecular modeling; salsolinol; µ-Opioid receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Opioides mu / Simulação de Dinâmica Molecular / Isoquinolinas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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