Tumor Heterogeneity as a Predictor of Response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer.

Greenbaum, Alissa; Martin, David R; Bocklage, Thèrése; Lee, Ji-Hyun; Ness, Scott A; Rajput, Ashwani

Greenbaum, Alissa; Martin, David R; Bocklage, Thèrése; Lee, Ji-Hyun; Ness, Scott A; Rajput, Ashwani.

Afiliação

Greenbaum A; Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM.
Martin DR; Department of Pathology, University of New Mexico, Albuquerque, NM.
Bocklage T; Department of Pathology and Laboratory Medicine, University of Kentucky Albert B. Chandler Hospital, Lexington, KY.
Lee JH; Department of Biostatistics, College of Public Health and Health Professions College of Medicine, University of Florida, Gainesville, FL.
Ness SA; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM.
Rajput A; Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM. Electronic address: arajput@salud.unm.edu.

Clin Colorectal Cancer ; 18(2): 102-109, 2019 06.

Article em En | MEDLINE | ID: mdl-30935775

Assuntos

Adenocarcinoma/terapia; Biomarcadores Tumorais/genética; Quimiorradioterapia Adjuvante/métodos; Terapia Neoadjuvante/métodos; Neoplasias Retais/terapia; Adenocarcinoma/genética; Adenocarcinoma/mortalidade; Alelos; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Biópsia; Análise Mutacional de DNA; Feminino; Heterogeneidade Genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Mutação; Estadiamento de Neoplasias; Seleção de Pacientes; Protectomia; Prognóstico; Estudos Prospectivos; Neoplasias Retais/genética; Neoplasias Retais/mortalidade; Reto/patologia; Reto/cirurgia; Análise de Sobrevida; Resultado do Tratamento

Palavras-chave

Bioinformatics; Colorectal cancer; Personalized medicine; Targeted sequencing; Translational research

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Adenocarcinoma / Biomarcadores Tumorais / Terapia Neoadjuvante / Quimiorradioterapia Adjuvante Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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