Autonomic Nervous System Modifications During Wakefulness and Sleep in a Cohort of Patients with Acute Ischemic Stroke.
J Stroke Cerebrovasc Dis
; 28(6): 1455-1462, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30935807
ABSTRACT
GOAL The aims of our study were to investigate autonomic modifications in wakefulness and sleep in a cohort of patients with acute ischemic stroke and to evaluate whereas these modifications were dependent by sleep stage and stroke lateralization. MATERIALS AND METHODS:
We prospectively enrolled 42 patients (22 men and 20 women, mean age 69.8 ± 11.3; range 32-92 years) with acute ischemic stroke. All participants underwent a full-night polysomnography. As index of autonomic nervous system we used Heart Rate Variability (HRV), analyzed in wakefulness and during different sleep stages. First, we compared our cohort with a control group of 42 healthy subjects, matched for age and sex. Subsequently, we divided our cohort in 2 subgroups according stroke lateralization (21 right, 21 left) and compared with control population.FINDINGS:
We observed significant modifications of HRV parameters mainly for the right lesions. In particular, we observed a prevalent parasympathetic tone during the wake (low frequency/high frequency [LF/HF] right 2.99 ± 8.91; controls 3.88 ± 3.42; P < .01) and during REM (LF/HF right 0.03 ± 1.58; controls 2.92 ± 3.97; P < .01) accompanied by a significant reduction of sympathetic tone during REM (LF right 23.85 ± 44.42 n.u.; controls 51.13 ± 32.25 n.u.; P < .01), and by a reduction of parasympathetic tone during N3 (HF right 28.09 ± 37.67 n.u.; controls 43.08 ± 68.39 n.u.; P < .01).CONCLUSIONS:
Our study indicates that autonomic dysfunctions in acute ischemic stroke are prevalent in right-side lesions and strictly dependent by sleep-wake stage.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fases do Sono
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Sistema Nervoso Autônomo
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Vigília
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Isquemia Encefálica
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Acidente Vascular Cerebral
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Coração
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Frequência Cardíaca
Tipo de estudo:
Diagnostic_studies
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Observational_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article