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Author Correction: Testing the key assumption of heritability estimates based on genome-wide genetic relatedness.
Conley, Dalton; Siegal, Mark L; Domingue, Benjamin W; Harris, Kathleen Mullan; McQueen, Matthew B; Boardman, Jason D.
Afiliação
  • Conley D; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA. daltonclarkconley@gmail.com.
  • Siegal ML; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.
  • Domingue BW; Institute for Behavioral Science, University of Colorado, Boulder, CO, USA.
  • Harris KM; Department of Sociology, University of North Carolina, Chapel Hill, NC, USA.
  • McQueen MB; Department of Integrative Physiology, University of Colorado, Boulder, CO, USA.
  • Boardman JD; Institute for Behavioral Science, University of Colorado, Boulder, CO, USA.
J Hum Genet ; 64(6): 597-598, 2019 06.
Article em En | MEDLINE | ID: mdl-30940889
ABSTRACT
In the original paper, we used the variable "URBRUR08," from the 2008 survey wave as a measure of childhood urbanicity. Upon further investigation we realized that this variable actually measured Beale urban-rural code during the respondent's adulthood.  Thus, we reran our analysis of the pseudo-heritability of childhood urbanicity using the variable. The original results hold such that even with the first 20 principal components held constant, childhood urban-rural status appears to be ~20% "heritable" in GREML models-a figure that is actually higher than the original estimate reported in the paper (14% controlling for 25 PCs, 15% controlling for 10 PCs, and 29% controlling for two PCs). Meanwhile, the heritabilities of the other phenotypes-height, BMI and education-still do not change when they are residualized on childhood urbanicity. In other words, the original results of the paper do not change.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article