Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
Eur J Med Chem
; 172: 71-94, 2019 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-30947123
Palavras-chave
1-(3-dimethylaminopropyl)-3-ethylcarbodiimmide hydrochloride; 4-Dimethylaminopyridine; ATPase activity; Apparent permeability; BCRP; BCRP modulators; Breast cancer resistance protein; Caco-2â¯cells; Colorectal adenocarcinoma cells; DMAP; DOX; Doxorubicin; EDCI; Human plasma stability; KEE; Ketoprofen Ethyl Ester; MDCK; MDR reversers; MRP1; MRP1 modulators; Madin-Darby Canin Kidney; Molecular docking; Multidrug resistance associated protein 1; P-glycoprotein; P-gp; P-gp modulators; PBS; PDB; Phosphate buffer solution; Pirarubicin uptake; Protein data bank; Rhd123; Rhodamine-123; Rhodamine-123 efflux; TPSA; Topological polar surface area
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Resistência a Múltiplos Medicamentos
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Resistencia a Medicamentos Antineoplásicos
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Ésteres
/
Aminas
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article