Amyloid-ß oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.

Bode, David C; Freeley, Mark; Nield, Jon; Palma, Matteo; Viles, John H

Bode, David C; Freeley, Mark; Nield, Jon; Palma, Matteo; Viles, John H.

Afiliação

Bode DC; From the School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom.
Freeley M; From the School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom.
Nield J; From the School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom.
Palma M; From the School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom.
Viles JH; From the School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom j.viles@qmul.ac.uk.

J Biol Chem ; 294(19): 7566-7572, 2019 05 10.

Article em En | MEDLINE | ID: mdl-30948512

Assuntos

Doença de Alzheimer; Peptídeos beta-Amiloides/química; Bicamadas Lipídicas/química; Multimerização Proteica; Peptídeos beta-Amiloides/metabolismo; Humanos; Bicamadas Lipídicas/metabolismo

Palavras-chave

Alzheimer disease; amyloid-beta (AB); atomic force microscopy (AFM); cytotoxicity; electron microscopy (EM); large unilamellar vesicles; membrane bilayer; membrane disruption; mica surface; nanoscale imaging; neurodegeneration; oligomer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Multimerização Proteica / Doença de Alzheimer / Bicamadas Lipídicas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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