Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia.

Schittenhelm, Marcus Matthias; Walter, Bianca; Tsintari, Vasileia; Federmann, Birgit; Bajrami Saipi, Mihada; Akmut, Figen; Illing, Barbara; Mau-Holzmann, Ulrike; Fend, Falko; Lopez, Charles Darin; Kampa-Schittenhelm, Kerstin Maria

Schittenhelm, Marcus Matthias; Walter, Bianca; Tsintari, Vasileia; Federmann, Birgit; Bajrami Saipi, Mihada; Akmut, Figen; Illing, Barbara; Mau-Holzmann, Ulrike; Fend, Falko; Lopez, Charles Darin; Kampa-Schittenhelm, Kerstin Maria.

Afiliação

Schittenhelm MM; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Walter B; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Tsintari V; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Federmann B; Institute of General and Molecular Pathology and Pathological Anatomy, University Hospital Tübingen, Germany.
Bajrami Saipi M; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Akmut F; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Illing B; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany.
Mau-Holzmann U; Institute of Medical Genetics, University Hospital Tübingen, Germany.
Fend F; Institute of General and Molecular Pathology and Pathological Anatomy, University Hospital Tübingen, Germany.
Lopez CD; Department of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR, United States of America.
Kampa-Schittenhelm KM; Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Germany. Electronic address: kerstin.kampa-schittenhelm@med.uni-tuebingen.de.

EBioMedicine ; 42: 340-351, 2019 Apr.

Article em En | MEDLINE | ID: mdl-30952616

Assuntos

Processamento Alternativo; Proteínas Reguladoras de Apoptose/genética; Genes Supressores de Tumor; Leucemia Mieloide Aguda/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Estresse Fisiológico/genética; Proteínas Reguladoras de Apoptose/metabolismo; Linhagem Celular Tumoral; Citogenética; Regulação Neoplásica da Expressão Gênica; Humanos; Leucemia Mieloide Aguda/metabolismo; Células-Tronco Neoplásicas/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo; Biossíntese de Proteínas; Isoformas de Proteínas/genética; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

ASPP2; Acute leukemia; Alternative splicing; Oncogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Leucemia Mieloide Aguda / Genes Supressores de Tumor / Processamento Alternativo / Proteínas Reguladoras de Apoptose / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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