Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity.

Al-Qahtani, Ahmed A; Murugaiah, Valarmathy; Bashir, Hani A; Pathan, Ansar A; Abozaid, Suhair M; Makarov, Evgeny; Nal-Rogier, Beatrice; Kishore, Uday; Al-Ahdal, Mohammed N

Al-Qahtani, Ahmed A; Murugaiah, Valarmathy; Bashir, Hani A; Pathan, Ansar A; Abozaid, Suhair M; Makarov, Evgeny; Nal-Rogier, Beatrice; Kishore, Uday; Al-Ahdal, Mohammed N.

Afiliação

Al-Qahtani AA; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Alfaisal University College of Medicine, Riyadh, Saudi Arabia.
Murugaiah V; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Bashir HA; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Pathan AA; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Abozaid SM; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Makarov E; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Nal-Rogier B; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Kishore U; Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom.
Al-Ahdal MN; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Alfaisal University College of Medicine, Riyadh, Saudi Arabia. Electronic address: profahdal@gmail.com.

Immunobiology ; 224(3): 408-418, 2019 05.

Article em En | MEDLINE | ID: mdl-30954271

Assuntos

Antivirais/metabolismo; Células Epiteliais/fisiologia; Vírus da Influenza A Subtipo H1N1/fisiologia; Vírus da Influenza A Subtipo H3N2/fisiologia; Influenza Humana/imunologia; Pulmão/patologia; Proteína A Associada a Surfactante Pulmonar/metabolismo; Quimiocina CCL5/metabolismo; Citocinas/metabolismo; Células Epiteliais/virologia; Glicosilação; Humanos; Mediadores da Inflamação/metabolismo; Ligação Proteica; Domínios Proteicos/genética; Proteína A Associada a Surfactante Pulmonar/genética; Proteínas Recombinantes/genética; Virulência; Replicação Viral

Palavras-chave

Influenza A virus; Innate immunity; Pulmonary collectins; Surfactant protein A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Proteína A Associada a Surfactante Pulmonar / Células Epiteliais / Influenza Humana / Vírus da Influenza A Subtipo H1N1 / Vírus da Influenza A Subtipo H3N2 / Pulmão Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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