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Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Thalji, Reema K; Raha, Kaushik; Andreotti, Daniele; Checchia, Anna; Cui, Haifeng; Meneghelli, Giovanni; Profeta, Roberto; Tonelli, Federica; Tommasi, Simona; Bakshi, Tania; Donovan, Brian T; Howells, Alison; Jain, Shruti; Nixon, Christopher; Quinque, Geoffrey; McCloskey, Lynn; Bax, Benjamin D; Neu, Margarete; Chan, Pan F; Stavenger, Robert A.
Afiliação
  • Thalji RK; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Raha K; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Andreotti D; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Checchia A; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Cui H; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Meneghelli G; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Profeta R; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Tonelli F; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Tommasi S; EVOTEC Center of Drug Discovery and Development, 37135 Verona, Italy.
  • Bakshi T; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Donovan BT; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Howells A; Inspiralis Ltd. Innovation Centre, Norwich NR4 7GJ, UK.
  • Jain S; Inspiralis Ltd. Innovation Centre, Norwich NR4 7GJ, UK.
  • Nixon C; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Quinque G; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • McCloskey L; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Bax BD; GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NYH, UK.
  • Neu M; GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NYH, UK.
  • Chan PF; GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Stavenger RA; GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: robert.a.stavenger@gsk.com.
Bioorg Med Chem Lett ; 29(11): 1407-1412, 2019 06 01.
Article em En | MEDLINE | ID: mdl-30962087
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / DNA Girase / Acinetobacter baumannii / Escherichia coli / Inibidores da Topoisomerase II / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / DNA Girase / Acinetobacter baumannii / Escherichia coli / Inibidores da Topoisomerase II / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article