Association between infection with Helicobacter pylori and platelet indices among school-aged children in central Ethiopia: a cross-sectional study.
BMJ Open
; 9(4): e027748, 2019 04 08.
Article
em En
| MEDLINE
| ID: mdl-30962240
ABSTRACT
OBJECTIVE:
Previous clinical studies in adults from developed countries have implicated Helicobacter pylori infections in the development of thrombocytopenia. However, studies in children, particularly those from low-income countries, are unusually scarce. We examined the association between H. pylori infection and platelet indices in young Ethiopian school children.DESIGN:
Cross-sectional studySETTING:
This study was conducted in five elementary schools located in central Ethiopia.PARTICIPANTS:
Blood and stool samples were collected from 971 children across five elementary schools in Ethiopia. H. pylori infection was diagnosed using stool antigen and serum antibody tests, and haematological parameters were measured using an automated haematological analyser. An interviewer-led questionnaire administered to mothers provided information on demographic and lifestyle variables. The independent effects of H. pylori infection on platelet indices were determined using multivariate linear and logistic regressions. STUDYOUTCOMES:
H. pylori-infected children had a lower average platelet count and mean platelet volume than uninfected after adjusting the potential confounders (adjusted mean difference -20.80×109/L; 95% CI -33.51 to -8.09×109, p=0.001 and adjusted mean difference -0.236 fL; 95% CI -0.408 to -0.065, p=0.007, respectively). Additionally, H. pylori-infected children had lower red blood cell counts (adjusted mean difference -0.118×1012/L; 95% CI -0.200 to -0.036, p=0.005) compared with non-infected.CONCLUSION:
Our study from a developing country provides further support for an association between H. pylori infections and reduced platelet indices in young Ethiopian school children, after controlling for potential confounders. Further research is needed, particularly longitudinal studies, to establish causality.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Contagem de Plaquetas
/
Infecções por Helicobacter
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article