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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie, Susan; Brand, Stephen; Thomas, Michael; De Rycker, Manu; Chung, Chun-Wa; Pena, Imanol; Bingham, Ryan P; Bueren-Calabuig, Juan A; Cantizani, Juan; Cebrian, David; Craggs, Peter D; Ferguson, Liam; Goswami, Panchali; Hobrath, Judith; Howe, Jonathan; Jeacock, Laura; Ko, Eun-Jung; Korczynska, Justyna; MacLean, Lorna; Manthri, Sujatha; Martinez, Maria S; Mata-Cantero, Lydia; Moniz, Sonia; Nühs, Andrea; Osuna-Cabello, Maria; Pinto, Erika; Riley, Jennifer; Robinson, Sharon; Rowland, Paul; Simeons, Frederick R C; Shishikura, Yoko; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Viayna Gaza, Elisabet; Wall, Richard J; Zuccotto, Fabio; Horn, David; Ferguson, Michael A J; Fairlamb, Alan H; Fiandor, Jose M; Martin, Julio; Gray, David W; Miles, Timothy J; Gilbert, Ian H; Read, Kevin D; Marco, Maria; Wyatt, Paul G.
Afiliação
  • Wyllie S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Brand S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Thomas M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • De Rycker M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Chung CW; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Pena I; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Bingham RP; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Bueren-Calabuig JA; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Cantizani J; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Cebrian D; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Craggs PD; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Ferguson L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Goswami P; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Hobrath J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Howe J; David Jack Centre for R&D, GlaxoSmithKline, Ware SG12 0DP, United Kingdom.
  • Jeacock L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Ko EJ; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Korczynska J; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • MacLean L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Manthri S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Martinez MS; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Mata-Cantero L; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Moniz S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Nühs A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Osuna-Cabello M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Pinto E; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Robinson S; David Jack Centre for R&D, GlaxoSmithKline, Ware SG12 0DP, United Kingdom.
  • Rowland P; Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Simeons FRC; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Shishikura Y; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Spinks D; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Thomas J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Thompson S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Viayna Gaza E; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Wall RJ; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Horn D; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Ferguson MAJ; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Fairlamb AH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Fiandor JM; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Martin J; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Gray DW; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Miles TJ; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain.
  • Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom; k.read@dundee.ac.uk maria.m.marco@gsk.com p.g.wyatt@dundee.ac.uk.
  • Marco M; Global Health R&D, GlaxoSmithKline, Tres Cantos, 28760, Spain; k.read@dundee.ac.uk maria.m.marco@gsk.com p.g.wyatt@dundee.ac.uk.
  • Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom; k.read@dundee.ac.uk maria.m.marco@gsk.com p.g.wyatt@dundee.ac.uk.
Proc Natl Acad Sci U S A ; 116(19): 9318-9323, 2019 05 07.
Article em En | MEDLINE | ID: mdl-30962368
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leishmania donovani / Proteínas de Protozoários / Leishmania infantum / Inibidores de Proteassoma / Leishmaniose Visceral / Antiprotozoários Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leishmania donovani / Proteínas de Protozoários / Leishmania infantum / Inibidores de Proteassoma / Leishmaniose Visceral / Antiprotozoários Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article