Increased level of high-sensitivity cardiac Troponin T in a geriatric population is determined by comorbidities compared to age.
Int J Cardiol Heart Vasc
; 22: 187-191, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30963093
ABSTRACT
High level of cardiac Troponin T (hs-cTnT) in geriatric population has been considered as an age-related phenomenon, which may question the interpretation of the increase of hs-cTnT in this population. The challenge is what is the primary cause of the increased hs-cTnT levels in elderly patients without AMI. OBJECTIVE:
The aim of the current study was to determine the impact of aging on hs-cTnT levels in elderly patients without acute cardiac events but in the presence of comorbidities.METHODS:
Sociodemographic and clinical data were collected from 6977 medical records of patients aged ≥65â¯years without acute coronary events but for whom hs-cTnT measurements were available. The patients were stratified based on age, troponin levels and the number of comorbidities.RESULTS:
The results suggested that the likelihood of increased hs-cTnT was related to the presence of comorbidities independently of their number (pâ¯<â¯0.05). The adjusted odds ratio (AOR) for both advanced age and having comorbidity was statistically significant, however for the old group (74â¯≥â¯ageâ¯≥â¯84â¯years) the chance of having elevated troponin regarding age compared to the presence of comorbidity was 1.070 vs. 1.216, whereas for the old-old group (≥85â¯years) it was found to be 1.071 vs. 1.311. Besides statistical significance for age, from a clinical standpoint, the AOR of 1.070 may not be considered clinically relevant.CONCLUSION:
Increased hs-cTnT levels were associated with the presence of pre-existing comorbidities independently of age. Increased hs-cTnT levels in the elderly should always be considered as pathological, and a specific etiology should be searched.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article