Being in a loop: how long non-coding RNAs organise genome architecture.
Essays Biochem
; 63(1): 177-186, 2019 04 23.
Article
em En
| MEDLINE
| ID: mdl-30967478
ABSTRACT
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635-1655; PLoS ONE (2007) 2, e1182; Nat. Genet. (2002) 30, 329-334]. Long non-coding RNAs (lncRNAs) are able to control chromatin structure through nucleosome positioning, interaction with chromatin re-modellers and chromosome looping. These functions are carried out in cis at the site of lncRNAs transcription or in trans at distant loci. While the evidence for a role in lncRNAs in regulating gene expression through chromatin interactions is increasing, there is still very little conclusive evidence for a potential role in looping organisation. Here, we review models for the involvement of lncRNAs in genome architecture and the experimental evidence to support them.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Genoma
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RNA Longo não Codificante
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article