Antigenic Mimicry in Paraneoplastic Immune Thrombocytopenia.
Front Immunol
; 10: 523, 2019.
Article
em En
| MEDLINE
| ID: mdl-30967864
ABSTRACT
The association of immune thrombocytopenia (ITP) with cancer has been reported, but the causality of tumor cells in paraneoplastic ITP pathogenesis and maintenance has never been established. We analyzed the unusual case of refractory ITP and coincident urothelial tumor of the kidney with circulating high titer anti-GPIIBIIIA autoantibodies. Intriguingly, after nephrectomy, the patient recovered fully and her anti-GPIIBIIIA autoantibodies disappeared. Proteomic and immunohistochemistry analyses revealed erratic GPIIB expression by the tumor cells, suggesting possible antigenic mimicry chronically stimulating the immune system and leading to this patient's refractory ITP. Such previously unreported findings provide proof-of-concept that requires further confirmation with the prospective study of a larger number of patients.
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Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
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Autoanticorpos
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Púrpura Trombocitopênica Idiopática
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Mimetismo Molecular
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Complexo Glicoproteico GPIIb-IIIa de Plaquetas
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Neoplasias Renais
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Antígenos de Neoplasias
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article