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CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110ß and predicts poor prognosis.
Ma, Xiao-Lu; Shen, Min-Na; Hu, Bo; Wang, Bei-Li; Yang, Wen-Jing; Lv, Li-Hua; Wang, Hao; Zhou, Yan; Jin, An-Li; Sun, Yun-Fan; Zhang, Chuan-Yan; Qiu, Shuang-Jian; Pan, Bai-Shen; Zhou, Jian; Fan, Jia; Yang, Xin-Rong; Guo, Wei.
Afiliação
  • Ma XL; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Shen MN; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Hu B; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Wang BL; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Yang WJ; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Lv LH; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Wang H; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Zhou Y; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Jin AL; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Sun YF; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Zhang CY; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Qiu SJ; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Pan BS; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China.
  • Zhou J; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Fan J; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Yang XR; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China. yang.xinrong@zs-hospital.sh.cn.
  • Guo W; Liver Cancer Institute, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. yang.xinrong@zs-hospital.sh.cn.
J Hematol Oncol ; 12(1): 37, 2019 04 11.
Article em En | MEDLINE | ID: mdl-30971294
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Carcinoma Hepatocelular / Fosfatidilinositol 3-Quinases / Proteínas de Ligação a Telômeros / Proteínas Proto-Oncogênicas c-akt / Classe II de Fosfatidilinositol 3-Quinases / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Carcinoma Hepatocelular / Fosfatidilinositol 3-Quinases / Proteínas de Ligação a Telômeros / Proteínas Proto-Oncogênicas c-akt / Classe II de Fosfatidilinositol 3-Quinases / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article