Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders.
Int J Mol Sci
; 20(7)2019 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-30974904
ABSTRACT
Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and optic neuritis. Despite the known therapeutic role and mechanisms of MSCs, low cell precision towards the targeted area and cell survivability at tissue needing repair often resulted in a disparity in therapeutic outcomes. In this review, we will discuss the current and feasible strategy options to enhance treatment outcomes with MSC therapy. We will review the application of various types of biomaterials and advances in nanotechnology, which have been employed on MSCs to augment cellular function and differentiation for improving treatment of visual functions. In addition, several modes of gene delivery into MSCs and the types of associated therapeutic genes that are important for modulation of ocular tissue function and repair will be highlighted.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neurite Óptica
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Retinose Pigmentar
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Glaucoma
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Transplante de Células-Tronco Mesenquimais
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Retinopatia Diabética
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Células-Tronco Mesenquimais
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article