Carnitine Profile by Tandem Mass Spectrometry and Dialysis Patients.
Contrib Nephrol
; 198: 73-77, 2019.
Article
em En
| MEDLINE
| ID: mdl-30991404
ABSTRACT
BACKGROUND:
Carnitine deficiency is a common condition in hemodialysis patients. Therefore, abnormalities in fatty acid metabolism and organic acid metabolism are also common in dialysis patients. Tandem mass spectrometry is a standard technique in pediatric and neonatal medicine. However, it could be a new powerful tool in other fields for estimating the state of intracellular fatty acid metabolism.SUMMARY:
Tandem mass spectrometry has recently revealed the relationships between carnitine profile and dialysis patients' anemia, reduced physical function, and survival rate. Fatty acid and organic acid metabolism, which could previously only be evaluated qualitatively, can now be quantitatively assessed. Key Message The applications of tandem mass spectrometry are expected to expand not only in the field of dialysis but also in clinical medicine in general.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carnitina
/
Diálise Renal
/
Hiperamonemia
/
Espectrometria de Massas em Tandem
/
Doenças Musculares
/
Cardiomiopatias
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article