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Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404).
Kato, Hikaru; Sebe, Momona; Nagaki, Mika; Eguchi, Keisuke; Kagiyama, Ippei; Hitora, Yuki; Frisvad, Jens C; Williams, Robert M; Tsukamoto, Sachiko.
Afiliação
  • Kato H; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Sebe M; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Nagaki M; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Eguchi K; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Kagiyama I; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Hitora Y; Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.
  • Frisvad JC; Section for Eukaryotic Biotechnology, Departments of System Biology , Technical University of Denmark , Building 221, 2800 Kongens Lyngby , Denmark.
  • Williams RM; Department of Chemistry , Colorado State University , 301 West Pitkin Street , Fort Collins , Colorado 80523 , United States.
  • Tsukamoto S; University of Colorado Cancer Center , Aurora , Colorado 80045 , United States.
J Nat Prod ; 82(5): 1377-1381, 2019 05 24.
Article em En | MEDLINE | ID: mdl-30995043
ABSTRACT
Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 µM, whereas 2-4 were nontoxic at 50 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus / Diterpenos / Antibióticos Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus / Diterpenos / Antibióticos Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article