Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.
Immunity
; 50(4): 778-795, 2019 04 16.
Article
em En
| MEDLINE
| ID: mdl-30995499
ABSTRACT
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Interleucina-1
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Imunidade Adaptativa
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Imunidade Inata
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Inflamação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article