The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications.
Cell
; 177(3): 521-523, 2019 04 18.
Article
em En
| MEDLINE
| ID: mdl-31002793
ABSTRACT
Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Proteínas de Saccharomyces cerevisiae
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article