Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights.

Laufer, Benjamin I; Hwang, Hyeyeon; Vogel Ciernia, Annie; Mordaunt, Charles E; LaSalle, Janine M

Laufer, Benjamin I; Hwang, Hyeyeon; Vogel Ciernia, Annie; Mordaunt, Charles E; LaSalle, Janine M.

Afiliação

Laufer BI; a Department of Medical Microbiology and Immunology, School of Medicine , Genome Center, MIND Institute, University of California , Davis , CA , USA.
Hwang H; a Department of Medical Microbiology and Immunology, School of Medicine , Genome Center, MIND Institute, University of California , Davis , CA , USA.
Vogel Ciernia A; a Department of Medical Microbiology and Immunology, School of Medicine , Genome Center, MIND Institute, University of California , Davis , CA , USA.
Mordaunt CE; a Department of Medical Microbiology and Immunology, School of Medicine , Genome Center, MIND Institute, University of California , Davis , CA , USA.
LaSalle JM; a Department of Medical Microbiology and Immunology, School of Medicine , Genome Center, MIND Institute, University of California , Davis , CA , USA.

Epigenetics ; 14(7): 672-684, 2019 07.

Article em En | MEDLINE | ID: mdl-31010359

Assuntos

Encéfalo/metabolismo; Metilação de DNA/genética; Síndrome de Down/genética; Lobo Frontal/metabolismo; Encéfalo/patologia; Ilhas de CpG/genética; Síndrome de Down/patologia; Epigênese Genética/genética; Lobo Frontal/patologia; Genoma Humano/genética; Humanos; Masculino; Sequenciamento Completo do Genoma

Palavras-chave

DMRs; DNA methylation; Down syndrome; Epigenomics; WGBS; brain; differentially methylated regions; whole genome bisulfite sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Síndrome de Down / Metilação de DNA / Lobo Frontal Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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