The olfactory bulb: A link between environmental agents and narcolepsy.
Med Hypotheses
; 126: 66-68, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-31010502
ABSTRACT
Narcolepsy with cataplexy is a lifelong sleep disorder associated with orexin/hypocretin deficiency in the central nervous system. In addition to a genetic predisposition, a variety of environmental factors, such as influenza viruses, have been implicated in the pathogenesis of the disease. In this article, a hypothesis is proposed that environmental agents access the olfactory bulb and trigger neuroinflammation, which in turn induces neurodegeneration of orexinergic neurons in the lateral hypothalamus and other neuronal subpopulations regulating the sleep-wake cycle, which triggers the development of narcolepsy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Narcolepsia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article