Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria.
Medchemcomm
; 10(3): 484-487, 2019 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-31015912
ABSTRACT
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
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Article