2,3',4,4',5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2/PKD/VPS34 pathway.

Zhou, Qi; Wang, Li; Chen, Huanhuan; Xu, Bojin; Xu, Wenli; Sheng, Yunlu; Duan, Yu

Zhou, Qi; Wang, Li; Chen, Huanhuan; Xu, Bojin; Xu, Wenli; Sheng, Yunlu; Duan, Yu.

Afiliação

Zhou Q; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
Wang L; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
Chen H; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
Xu B; Endocrinology Department, School of Medicine, Shanghai Tongren Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Xu W; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
Sheng Y; Division of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Duan Y; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China. duanyujsph@163.com.

Arch Toxicol ; 93(6): 1639-1648, 2019 06.

Article em En | MEDLINE | ID: mdl-31020377

Assuntos

Autofagia/efeitos dos fármacos; Classe III de Fosfatidilinositol 3-Quinases/efeitos dos fármacos; Proteínas Quinases Associadas com Morte Celular/efeitos dos fármacos; Lipopeptídeos/efeitos dos fármacos; Bifenilos Policlorados/toxicidade; Células Epiteliais da Tireoide/efeitos dos fármacos; Animais; Relação Dose-Resposta a Droga; Masculino; Fagossomos/efeitos dos fármacos; RNA Interferente Pequeno/farmacologia; Ratos; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos; Tubulina (Proteína)/efeitos dos fármacos; Tubulina (Proteína)/genética

Palavras-chave

Autophagy; DAPK2/PKD/VPS34 pathway; PCB118; Thyroidal ultrastructure; Tubb3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Bifenilos Policlorados / Lipopeptídeos / Classe III de Fosfatidilinositol 3-Quinases / Proteínas Quinases Associadas com Morte Celular / Células Epiteliais da Tireoide Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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