Antithrombotic Activity of a Novel Diazepino[1,2-&#945;] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction.

Spasov, A A; Kucheryavenko, A F; Sirotenko, V S; Anisimova, V A; Divaeva, L N; Kuz'menko, T A; Morkovnik, A S

Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction.

Spasov, A A; Kucheryavenko, A F; Sirotenko, V S; Anisimova, V A; Divaeva, L N; Kuz'menko, T A; Morkovnik, A S.

Afiliação

Spasov AA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
Kucheryavenko AF; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. aidakucheryavenko@yandex.ru.
Sirotenko VS; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
Anisimova VA; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
Divaeva LN; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
Kuz'menko TA; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
Morkovnik AS; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.

Bull Exp Biol Med ; 166(6): 747-750, 2019 Apr.

Article em En | MEDLINE | ID: mdl-31020589

Assuntos

Azepinas/farmacologia; Benzimidazóis/farmacologia; Fibrinolíticos/farmacologia; Infarto do Miocárdio/tratamento farmacológico; Trombose/prevenção & controle; Animais; Animais não Endogâmicos; Aspirina/farmacologia; Azepinas/síntese química; Benzimidazóis/síntese química; Testes de Coagulação Sanguínea; Cloretos/administração & dosagem; Clopidogrel/farmacologia; Modelos Animais de Doenças; Compostos Férricos/administração & dosagem; Fibrinolíticos/síntese química; Masculino; Infarto do Miocárdio/sangue; Infarto do Miocárdio/patologia; Agregação Plaquetária/efeitos dos fármacos; Ratos; Trombose/sangue; Trombose/induzido quimicamente; Trombose/patologia

Palavras-chave

DAB-15 agent; antithrombotic action; myocardial infarction; thrombosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azepinas / Trombose / Benzimidazóis / Fibrinolíticos / Infarto do Miocárdio Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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