Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH.

Boeckmans, Joost; Buyl, Karolien; Natale, Alessandra; Vandenbempt, Valerie; Branson, Steven; De Boe, Veerle; Rogiers, Vera; De Kock, Joery; Rodrigues, Robim M; Vanhaecke, Tamara

Boeckmans, Joost; Buyl, Karolien; Natale, Alessandra; Vandenbempt, Valerie; Branson, Steven; De Boe, Veerle; Rogiers, Vera; De Kock, Joery; Rodrigues, Robim M; Vanhaecke, Tamara.

Afiliação

Boeckmans J; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Buyl K; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Natale A; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Vandenbempt V; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Branson S; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
De Boe V; Department of Urology, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
Rogiers V; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
De Kock J; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Rodrigues RM; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address: Robim.Marcelino.Rodrigues@vub.be.
Vanhaecke T; Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Pharmacol Res ; 144: 377-389, 2019 06.

Article em En | MEDLINE | ID: mdl-31028903

Assuntos

Chalconas/farmacologia; Hepatócitos/efeitos dos fármacos; Inflamação/tratamento farmacológico; Lipogênese/efeitos dos fármacos; Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico; Propionatos/farmacologia; Células Cultivadas; Hepatócitos/citologia; Hepatócitos/patologia; Humanos; Inflamação/complicações; Inflamação/patologia; Hepatopatia Gordurosa não Alcoólica/complicações; Hepatopatia Gordurosa não Alcoólica/patologia; Pele/citologia; Pele/efeitos dos fármacos; Pele/patologia; Células-Tronco/citologia; Células-Tronco/efeitos dos fármacos; Células-Tronco/patologia

Palavras-chave

Disease modelling; Elafibranor; Elafibranor (Pubchem CID: 9864881); Glucose (Pubchem CID: 5793); Human skin-derived precursors (hSKP); Insulin (Pubchem CID: 16131099); Non-alcoholic steatohepatitis (NASH); Palmitic acid (Pubchem CID: 985); Peroxisome proliferator-activated receptor (PPAR)-α/Î´; Sodium oleate (Pubchem CID: 23665730); Stem cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionatos / Hepatócitos / Chalconas / Lipogênese / Hepatopatia Gordurosa não Alcoólica / Inflamação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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