Execution of julolidine based derivative as bifunctional chemosensor for Zn2+ and Cu2+ ions: Applications in bio-imaging and molecular logic gate.
Spectrochim Acta A Mol Biomol Spectrosc
; 219: 33-43, 2019 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-31030045
ABSTRACT
A simple julolidine based chemosensor (JT) was designed and synthesized by single condensation step. JT displayed excellent selectivity and sensitivity with on-off responses towards Zn2+ and Cu2+ over other biologically relevant metal ions in aqueous media. Upon addition of Zn2+ ions, JT exhibited a significant blue shift in emission followed by turn-on enhancement while with Cu2+, the fluorescence intensity of JT was completely vanished. The 11 binding affinity between JT and Zn2+/Cu2+ was proposed by Job's plot analysis. The detection limit for Zn2+ and Cu2+ ions reached at 3.5â¯×â¯10-8â¯M and 1.46â¯×â¯10-6â¯M, respectively. The sensing mechanism of JT with Zn2+/Cu2+ was supported by DFT calculations. Based on photophysical studies and its reversibility environment with EDTA, molecular logic gates were fabricated. Furthermore, JT was successfully established to detect intracellular Zn2+ ions in live cells by turn-on response.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinolizinas
/
Zinco
/
Cobre
/
Corantes Fluorescentes
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article