A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67Cu.
Appl Radiat Isot
; 149: 89-95, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31035108
ABSTRACT
A novel method for the production of important medical radioisotopes has been developed. The approach is based on performing the nuclear reaction in inverse kinematics, namely sending a heavy-ion beam of appropriate energy on a light target (e.g. H, d, He) and collecting the isotope of interest. In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67Cu (T1/2â¯=â¯62â¯h) via the reaction of a 70Zn beam at 15 MeV/nucleon with a hydrogen gas target. The 67Cu radionuclide alongside other coproduced isotopes, was collected after the gas target on an aluminum catcher foil and their radioactivity was measured by off-line γ-ray analysis. After 36â¯h post irradiation, apart from the product of interest 67Cu, the main radioimpurity coming from the 70Zn + p reaction was 69mZn (T1/2â¯=â¯13.8â¯h), which can be reduced by further radio-cooling. Moreover, along with the radionuclide of interest produced in inverse kinematics, the production of additional radioisotopes is possible by making use of the forward-focused neutrons from the reaction and allowing them to interact with a secondary target. A preliminary successful test of this concept was realized in the present study. The main requirement to obtain activities appropriate for preclinical studies is the development of high-intensity heavy-ion primary beams.
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1
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Cobre
/
Compostos Radiofarmacêuticos
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Nanomedicina Teranóstica
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article