Hypereosinophilia and severe bone disease in an African child: an unexpected diagnosis.
BMJ Case Rep
; 12(4)2019 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-31036733
ABSTRACT
Hypereosinophilic syndromes are rare in children. Sporadic, mild-severity FIP1L1-platelet-derived growth factor receptor α (PDGFRα) rearrangement cases have been reported, mainly in boys. We present the case of a 5-year-old girl referred from her African country of birth, due to severe constitutional symptoms, multifocal bone pain, headache, gastrointestinal complaints, cardiomyopathy and unexplained hypereosinophilia. She presented multiple end-organ diseases and striking bone involvement. Although she had a positive serology for Strongyloides stercoralis, extensive evaluation detected a FIP1L1-PDGFRA fusion gene. Systemic corticosteroids and low-dose imatinib were started and the child became asymptomatic. After 9 months of treatment, FIP1L1-PDGFRA was no longer detected.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estrongiloidíase
/
Corticosteroides
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Síndrome Hipereosinofílica
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
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Child, preschool
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Female
/
Humans
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article