Idiosyncrasies of Viral Noncoding RNAs Provide Insights into Host Cell Biology.
Annu Rev Virol
; 6(1): 297-317, 2019 09 29.
Article
em En
| MEDLINE
| ID: mdl-31039329
Like their host cells, many viruses express noncoding RNAs (ncRNAs). Despite the technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been described, including regulation of viral replication, modulation of host gene expression, host immune evasion, cellular survival, and cellular transformation. Insights into conserved interactions between viral ncRNAs and host cell machinery frequently lead to novel findings concerning host cell biology. In this review, we discuss the functions and biogenesis of ncRNAs produced by animal viruses. Specifically, we describe noncanonical pathways of microRNA (miRNA) biogenesis and novel mechanisms used by viruses to manipulate miRNA and messenger RNA stability. We also highlight recent advances in understanding the function of viral long ncRNAs and circular RNAs.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vírus
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RNA Viral
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Regulação Viral da Expressão Gênica
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RNA não Traduzido
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Interações entre Hospedeiro e Microrganismos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article