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1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.
Li, Linsen; Okumu, Antony A; Nolan, Sheri; English, Anthony; Vibhute, Sandip; Lu, Yanran; Hervert-Thomas, Katherine; Seffernick, Justin T; Azap, Lovette; Cole, Serena L; Shinabarger, D; Koeth, Laura M; Lindert, Steffen; Yalowich, Jack C; Wozniak, Daniel J; Mitton-Fry, Mark J.
Afiliação
  • Li L; Division of Medicinal Chemistry and Pharmacognosy , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Okumu AA; Division of Medicinal Chemistry and Pharmacognosy , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Nolan S; Microbial Infection and Immunity , The Ohio State University , 460 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • English A; Division of Pharmacology , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Vibhute S; Division of Medicinal Chemistry and Pharmacognosy , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Lu Y; Division of Medicinal Chemistry and Pharmacognosy , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Hervert-Thomas K; Department of Chemistry , Ohio Wesleyan University , 61 South Sandusky Street , Delaware , Ohio 43015 , United States.
  • Seffernick JT; Department of Chemistry and Biochemistry , The Ohio State University , 100 West 18th Avenue , Columbus , Ohio 43210 , United States.
  • Azap L; Division of Medicinal Chemistry and Pharmacognosy , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Cole SL; Micromyx , 4717 Campus Drive , Kalamazoo , Michigan 49008 , United States.
  • Shinabarger D; Micromyx , 4717 Campus Drive , Kalamazoo , Michigan 49008 , United States.
  • Koeth LM; Laboratory Specialists, Inc. , 26214 Center Ridge Road , Westlake , Ohio 44145 , United States.
  • Lindert S; Department of Chemistry and Biochemistry , The Ohio State University , 100 West 18th Avenue , Columbus , Ohio 43210 , United States.
  • Yalowich JC; Division of Pharmacology , The Ohio State University , 500 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Wozniak DJ; Microbial Infection and Immunity , The Ohio State University , 460 West 12th Avenue , Columbus , Ohio 43210 , United States.
  • Mitton-Fry MJ; Department of Microbiology , The Ohio State University , 484 West 12th Avenue , Columbus , Ohio 43210 , United States.
ACS Infect Dis ; 5(7): 1115-1128, 2019 07 12.
Article em En | MEDLINE | ID: mdl-31041863
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Girase / Dioxanos / Staphylococcus aureus Resistente à Meticilina / Inibidores da Topoisomerase / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Girase / Dioxanos / Staphylococcus aureus Resistente à Meticilina / Inibidores da Topoisomerase / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article