Age-related analysis of the gut microbiome in a purebred dog colony.
FEMS Microbiol Lett
; 366(8)2019 04 01.
Article
em En
| MEDLINE
| ID: mdl-31049554
ABSTRACT
Dogs are model animals that can be used to study the gut microbiome. Although the gut microbiome is assumed to be closely related to aging, information pertaining to this relationship in dogs is limited. Here, we examined the association between the canine gut microbiome and age via a bacterial 16S rRNA gene amplicon sequence analysis in a colony of 43 Japanese purebred Shiba Inu dogs. We found that microbial diversity tended to decrease with aging. A differential abundance analysis showed an association of a single specific microbe with aging. The age-related coabundance network analysis showed that two microbial network modules were positively and negatively associated with aging, respectively. These results suggest that the dog gut microbiome is likely to vary with aging.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
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Variação Genética
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Envelhecimento
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Cães
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Microbioma Gastrointestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article