In vitro maturation rates in young premenarche patients.
Fertil Steril
; 112(2): 315-322, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31056316
ABSTRACT
OBJECTIVE:
To evaluate in vitro maturation (IVM) efficacy and oocyte retrieval rates after ovarian tissue cryopreservation in young premenarche girls facing chemo- and radiotherapy.DESIGN:
A retrospective cohort study.SETTING:
University-affiliated tertiary medical center. PATIENT(S) A total of 84 chemotherapy-naïve patients ages 0-18 years referred for fertility preservation between 2004 and 2017 33 premenarche and 51 postmenarche patients. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) IVM in the pre- and postmenarche groups and in the subgroups of very young (up to age 5 years) and older (5-10 years) premenarche girls.RESULTS:
The number of oocytes retrieved did not significantly differ between the postmenarche and premenarche groups (10.8 ± 8.5 and 8.1 ± 6.8, respectively). However, the overall IVM rate was significantly higher in the postmenarche group (28.2% vs. 15.5%, respectively; odds ratio = 0.47). A separate analysis for patients up to 5 years of age demonstrated significantly lower oocyte yield compared with the older (5-10 years) premenarche girls (4.7 ± 5.2 vs.10.3 ± 7.0 oocytes, respectively) and much lower IVM rates (4.9% and 18.2%, respectively). Correlation of age with number of retrieved and matured oocytes showed a positive significant correlation (r = 0.45 and r = 0.64, respectively).CONCLUSIONS:
IVM performed after ovarian tissue cryopreservation in premenarche girls and specifically in very young girls (4 years and younger) yields substantially decreased maturation rates compared with postmenarche patients, raising a question as to the utility of current IVM technique in this age group. Further studies are required to assess modification of the IVM technique for young girls.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oogênese
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Menarca
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Recuperação de Oócitos
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Técnicas de Maturação in Vitro de Oócitos
Tipo de estudo:
Observational_studies
Limite:
Child
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Child, preschool
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article