Actigraphy for evaluation of mood disorders: A systematic review and meta-analysis.
J Affect Disord
; 253: 257-269, 2019 06 15.
Article
em En
| MEDLINE
| ID: mdl-31060012
ABSTRACT
BACKGROUND:
Actigraphy has enabled consecutive observation of individual health conditions such as sleep or daily activity. This study aimed to examine the usefulness of actigraphy in evaluating depressive and/or bipolar disorder symptoms.METHOD:
A systematic review and meta-analysis was conducted. We selected studies that used actigraphy to compare either patients vs. healthy controls, or pre- vs. post-treatment data from the same patient group. Common actigraphy measurements, namely daily activity and sleep-related data, were extracted and synthesized.RESULTS:
Thirty-eight studies (nâ¯=â¯3,758) were included in the analysis. Compared with healthy controls, depressive patients were less active (standardized mean difference; SMD=1.27, 95%CI=[0.97, 1.57], P<0.001) and had longer wake after sleep onset (SMD=â¯-â¯0.729, 95%CI=[-â¯1.20, -â¯0.25], pâ¯=â¯0.003). Total sleep time (SMD=â¯-â¯0.33, 95%CI=[-â¯0.55, -â¯0.11], Pâ¯=â¯0.004), sleep latency (SMD=â¯-â¯0.22, 95%CI=[-â¯0.42, -â¯0.02], Pâ¯=â¯0.032), and wake after sleep onset (SMD=â¯-â¯0.22, 95%CI=[-â¯0.39, -â¯0.04], Pâ¯=â¯0.015) were longer in euthymic/remitted patients compared to healthy controls. In pre- and post-treatment comparisons, sleep latency (SMD=-â¯0.85, 95%CI=[-â¯1.53, -â¯0.17], Pâ¯=â¯0.015), wake after sleep onset (SMD=â¯-â¯0.65, 95%CI=[-â¯1.20, -â¯0.10], Pâ¯=â¯0.022), and sleep efficiency (SMD=0.77, 95%CI=[0.29, 1.24], Pâ¯=â¯0.002) showed significant improvement.LIMITATION:
The sample sizes for each outcome were small. The type of actigraphy devices and patients' illness severity differed across studies. It is possible that hospitalizations and medication influenced the outcomes.CONCLUSION:
We found significant differences between healthy controls and mood disorders patients for some actigraphy-measured modalities. Specific measurement patterns characterizing each mood disorder/status were also found. Additional actigraphy data linked to severity and/or treatment could enhance the clinical utility of actigraphy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Humor
/
Actigrafia
Tipo de estudo:
Diagnostic_studies
/
Systematic_reviews
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article