Population Pharmacokinetics of Anidulafungin in Critically Ill Patients.
Antimicrob Agents Chemother
; 63(7)2019 07.
Article
em En
| MEDLINE
| ID: mdl-31061150
ABSTRACT
A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of Candida albicans and Candida glabrata infections.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candidíase
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Estado Terminal
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Anidulafungina
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Antifúngicos
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article