Patch testing children with aluminium chloride hexahydrate in petrolatum: A review and a recommendation.
Contact Dermatitis
; 81(2): 81-88, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31066081
ABSTRACT
BACKGROUND:
According to studies on adults, patch testing with aluminium chloride hexahydrate 2% pet. is insufficient to detect aluminium allergy, and a 10% preparation is recommended. Other studies suggest that a 2% preparation is sufficient for testing children.OBJECTIVES:
To review three previously published Swedish studies on patch testing children with aluminium chloride hexahydrate 2% pet. PATIENTS/METHODS:
Altogether, 601 children with persistent itching subcutaneous nodules (granulomas) induced by aluminium-adsorbed vaccines were patch tested with aluminium chloride hexahydrate 2% pet. and metallic aluminium in (a) a pertussis vaccine trial, (b) clinical practice, and (c) a prospective study.RESULTS:
Overall, 459 children had positive reactions to the 2% pet. preparation. Another 10 reacted positively only to metallic aluminium. An extreme positive reaction (+++) was seen in 65% of children aged 1 to 2 years as compared with 22% of children aged 7 years. From 8 years onwards, extreme positive reactions were scarce.CONCLUSIONS:
Aluminium chloride hexahydrate 2% pet. is sufficient to trace aluminium allergy in children. Small children are at risk of extreme reactions. We thus suggest that aluminium chloride hexahydrate 10% pet. should not be used routinely in children before the age of 7 to 8 years.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testes do Emplastro
/
Alérgenos
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Dermatite Alérgica de Contato
/
Cloreto de Alumínio
Tipo de estudo:
Etiology_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article