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Neuronal loss or dysfunction in patients with early Lyme neuroborreliosis: a proton magnetic resonance spectroscopy study of the brain.
Garkowski, Adam; Kubas, Bozena; Hladunski, Marcin; Zajkowska, Joanna; Zajkowska, Olga; Jurgilewicz, Dorota; Zawadzki, Radoslaw; Garkowska, Ewa; Pancewicz, Slawomir; Lebkowska, Urszula.
Afiliação
  • Garkowski A; Department of Radiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276, Bialystok, Poland. adam.garkowski@gmail.com.
  • Kubas B; Independent Department, Laboratory of Molecular Imaging, Medical University of Bialystok, Bialystok, Poland.
  • Hladunski M; Independent Department, Laboratory of Molecular Imaging, Medical University of Bialystok, Bialystok, Poland.
  • Zajkowska J; Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.
  • Zajkowska O; Faculty of Applied Informatics and Mathematics, Warsaw University of Life Sciences SGGW, Warsaw, Poland.
  • Jurgilewicz D; Independent Department, Laboratory of Molecular Imaging, Medical University of Bialystok, Bialystok, Poland.
  • Zawadzki R; Department of Radiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276, Bialystok, Poland.
  • Garkowska E; Department of Radiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276, Bialystok, Poland.
  • Pancewicz S; Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.
  • Lebkowska U; Department of Radiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276, Bialystok, Poland.
J Neurol ; 266(8): 1937-1943, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31076877
BACKGROUND: We hypothesized that since Borrelia burgdorferi causes systemic inflammation and infects the brain, it may lead to alterations in cerebral metabolism, as measured by 1H-magnetic resonance spectroscopy (1H-MRS). The purpose of our study was to determine whether 1H-MRS could detect brain metabolite alterations in patients with early Lyme neuroborreliosis (LNB) in normal-appearing brain tissue on the conventional magnetic resonance imaging (MRI). METHODS: Twenty-six patients diagnosed with early LNB and twenty-six healthy volunteers as a control group have been involved in the study. All of them underwent routine MRI protocol using 3.0-T MRI scanner. 1H-MRS examinations were performed with repetition time (TR) = 2000 ms, and echo time (TE) = 135 ms. Single voxels were positioned in the anterior and posterior parts of the right and left frontal lobes. RESULTS: We found a statistically significant decrease of the N-acetylaspartate/creatine ratio within the anterior part of the right and left frontal lobes (p ≤ 0.001 and p = 0.001 respectively) and in the posterior part of the right and left frontal lobes (p ≤ 0.001 and 0.031) in the patients with LNB. CONCLUSION: A significant reduction in NAA/Cr ratio in comparison with the controls suggests the presence of diffuse neuronal loss in patients with early LNB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Neuroborreliose de Lyme / Espectroscopia de Prótons por Ressonância Magnética / Neurônios Tipo de estudo: Diagnostic_studies / Guideline / Screening_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Neuroborreliose de Lyme / Espectroscopia de Prótons por Ressonância Magnética / Neurônios Tipo de estudo: Diagnostic_studies / Guideline / Screening_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article