Ononin, sec-O-ß-d-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary.

Yu, Yunru; Li, Zhenhao; Guo, Rui; Qian, Jing; Zhang, Han; Zhang, Junhua; Zhao, Xiaoping; Wang, Shufang; Wang, Yi

Yu, Yunru; Li, Zhenhao; Guo, Rui; Qian, Jing; Zhang, Han; Zhang, Junhua; Zhao, Xiaoping; Wang, Shufang; Wang, Yi.

Afiliação

Yu Y; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Li Z; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Guo R; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Qian J; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang H; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang J; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhao X; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Wang S; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wang Y; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: zjuwangyi@zju.edu.cn.

Pharmacol Res ; 145: 104248, 2019 07.

Article em En | MEDLINE | ID: mdl-31082475

Assuntos

Antivirais/farmacologia; Cromonas/farmacologia; Glucosídeos/farmacologia; Isoflavonas/farmacologia; Saponinas/farmacologia; Triterpenos/farmacologia; Células HEK293; Ensaios de Triagem em Larga Escala; Humanos; Fatores Reguladores de Interferon/genética; Fatores Reguladores de Interferon/metabolismo; Luciferases/genética; Luciferases/metabolismo; Medicina Tradicional Chinesa

Palavras-chave

4'-O-ß-d-Glucosyl-5-O-methylvisamminol (CID 101784436); Anti-virus; High-throughput screening; Interferon stimulated response element; Knowledge mining; Ononin (CID 442813); Traditional Chinese medicines; astragaloside I (CID 13996685); prim-O-ß-d-Glucosylcimifugin (CID 14034912); sec-O-ß-d-Glucosylhamaudol (CID 10478277)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Saponinas / Triterpenos / Cromonas / Glucosídeos / Isoflavonas Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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