Your browser doesn't support javascript.
loading
Plasma Biomarkers of Human Immunodeficiency Virus-Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy.
Kroeze, Stefanie; Wit, Ferdinand W; Rossouw, Theresa M; Steel, Helen C; Kityo, Cissy M; Siwale, Margaret; Akanmu, Sulaimon; Mandaliya, Kishor; de Jager, Marleen; Ondoa, Pascale; Reiss, Peter; Rinke de Wit, Tobias F; Kootstra, Neeltje; Hamers, Raph L.
Afiliação
  • Kroeze S; Amsterdam Institute for Global Health and Development and Department of Global Health, Amsterdam, the Netherlands.
  • Wit FW; Amsterdam Institute for Global Health and Development and Department of Global Health, Amsterdam, the Netherlands.
  • Rossouw TM; Department of Internal Medicine, Division of Infectious Diseases, and Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.
  • Steel HC; Stichting HIV Monitoring, Amsterdam, the Netherlands.
  • Kityo CM; Department of Immunology, Institute for Cellular and Molecular Medicine, University of Pretoria, Pretoria, South Africa.
  • Siwale M; Department of Immunology, Institute for Cellular and Molecular Medicine, University of Pretoria, Pretoria, South Africa.
  • Akanmu S; Joint Clinical Research Centre, Kampala, Uganda.
  • Mandaliya K; Lusaka Trust Hospital, Zambia.
  • de Jager M; Department of Haematology and Blood Transfusion, College of Medicine of the University of Lagos and the Lagos University Teaching Hospital, Nigeria.
  • Ondoa P; Coast Province General Hospital, Mombasa, Kenya.
  • Reiss P; Muelmed Hospital, Pretoria, South Africa.
  • Rinke de Wit TF; Amsterdam Institute for Global Health and Development and Department of Global Health, Amsterdam, the Netherlands.
  • Kootstra N; African Society of Laboratory Medicine, Addis Ababa, Ethiopia.
  • Hamers RL; Amsterdam Institute for Global Health and Development and Department of Global Health, Amsterdam, the Netherlands.
J Infect Dis ; 220(6): 1029-1033, 2019 08 09.
Article em En | MEDLINE | ID: mdl-31086991
We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)-infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive protein, soluble CD163, and soluble scavenger receptor CD14 were significantly higher during ART than in an HIV-uninfected reference group (n = 90), indicating persistent monocyte/macrophage activation, inflammation, and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. Chemokine (C-C motif) ligand 2, lipopolysaccharide-binding protein, C-reactive protein, and interleukin 6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Glicoproteínas de Membrana / Antígenos de Diferenciação Mielomonocítica / Proteínas de Transporte / Antígenos CD / Infecções por HIV / HIV-1 / Interleucina-6 / Receptores de Superfície Celular / Quimiocina CCL2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Glicoproteínas de Membrana / Antígenos de Diferenciação Mielomonocítica / Proteínas de Transporte / Antígenos CD / Infecções por HIV / HIV-1 / Interleucina-6 / Receptores de Superfície Celular / Quimiocina CCL2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article