Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose-Stimulated Insulin Secretion in ß-Cells.
Chemistry
; 25(39): 9287-9294, 2019 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-31087418
ABSTRACT
The cyclic depsipeptide cereulide toxin it is a very well-known potassium electrogenic ionophore particularly sensitive to pancreatic beta cells. The mechanistic details of its specific activity are unknown. Here, we describe a series of synthetic substituted cereulide potassium ionophores that cause impressive selective activation of glucose-induced insulin secretion in a constitutive manner in rat insulinoma INS1E cells. Our study demonstrates that the different electroneutral K+ transport mechanism exhibited by the anionic mutant depsipeptides when compared with classical electrogenic cereulides can have an important impact of pharmacological value on glucose-stimulated insulin secretion.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Depsipeptídeos
/
Secreção de Insulina
/
Ionóforos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article