Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides.
Org Lett
; 21(11): 4255-4258, 2019 06 07.
Article
em En
| MEDLINE
| ID: mdl-31095399
ABSTRACT
A practical synthesis of α-fluorinated imides via the catalyst-free fluorohydroxylation of ynamides is developed. The reaction employs commercially available Selectfluor (F-TEDA-BF4) and H2O as the fluorine and hydroxyl sources, respectively. A broad range of aryl- or alkyl-substituted ynamides were well applicable to the reaction with good functional group tolerance under simple and mild reaction conditions. The synthetic utility of the α-fluoroimide products was demonstrated by several value-added transformations. Preliminary mechanistic studies were conducted.
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MEDLINE
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En
Ano de publicação:
2019
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Article