Postexposure Administration of a Yersinia pestis Live Vaccine for Potentiation of Second-Line Antibiotic Treatment Against Pneumonic Plague.
J Infect Dis
; 220(7): 1147-1151, 2019 08 30.
Article
em En
| MEDLINE
| ID: mdl-31095689
ABSTRACT
Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peste
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Yersinia pestis
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Ceftriaxona
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Vacinas Bacterianas
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Profilaxia Pós-Exposição
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Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article