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De novo design of tunable, pH-driven conformational changes.
Boyken, Scott E; Benhaim, Mark A; Busch, Florian; Jia, Mengxuan; Bick, Matthew J; Choi, Heejun; Klima, Jason C; Chen, Zibo; Walkey, Carl; Mileant, Alexander; Sahasrabuddhe, Aniruddha; Wei, Kathy Y; Hodge, Edgar A; Byron, Sarah; Quijano-Rubio, Alfredo; Sankaran, Banumathi; King, Neil P; Lippincott-Schwartz, Jennifer; Wysocki, Vicki H; Lee, Kelly K; Baker, David.
Afiliação
  • Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Benhaim MA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Busch F; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Jia M; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
  • Bick MJ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
  • Choi H; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Klima JC; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Chen Z; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
  • Walkey C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Mileant A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Sahasrabuddhe A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Wei KY; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Hodge EA; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
  • Byron S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Quijano-Rubio A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Sankaran B; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
  • King NP; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
  • Lippincott-Schwartz J; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
  • Wysocki VH; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Lee KK; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Baker D; Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
Science ; 364(6441): 658-664, 2019 05 17.
Article em En | MEDLINE | ID: mdl-31097662
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conformação Proteica / Engenharia de Proteínas / Multimerização Proteica Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conformação Proteica / Engenharia de Proteínas / Multimerização Proteica Idioma: En Ano de publicação: 2019 Tipo de documento: Article